Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940164 | 0.93 | KMT2A (0.43) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14939708 | 0.90 | KMT2A (0.42) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14940207 | 0.88 | ALDH1A1 (0.46) | KMT2AALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL14938926 | 0.86 | NPSR1 (0.38) | KMT2AALDH1A1MEN1GAANPSR1 | |
| SCHEMBL14939089 | 0.86 | KMT2A (0.42) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14939091 | 0.86 | KMT2A (0.42) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14939559 | 0.86 | KMT2A (0.42) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14938855 | 0.85 | ALDH1A1 (0.38) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14940190 | 0.85 | ALDH1A1 (0.37) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL14939099 | 0.83 | KMT2A (0.43) | KMT2AALDH1A1MEN1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |