Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940114 | 0.93 | NPSR1 (0.41) | NPSR1ALDH1A1GAAMAPTLMNA | |
| SCHEMBL14939343 | 0.91 | NPSR1 (0.51) | NPSR1ALDH1A1GAAMAPTTP53 | |
| SCHEMBL14939945 | 0.90 | NPSR1 (0.44) | NPSR1ALDH1A1GAAMAPTTP53 | |
| SCHEMBL14939842 | 0.90 | NPSR1 (0.50) | NPSR1ALDH1A1GAAMAPTTP53 | |
| SCHEMBL14939943 | 0.88 | NPSR1 (0.41) | NPSR1ALDH1A1MAPTTP53LMNA | |
| SCHEMBL14939141 | 0.87 | HTR7 (0.44) | NPSR1ALDH1A1MAPTTP53LMNA | |
| SCHEMBL14938747 | 0.87 | NPSR1 (0.44) | NPSR1ALDH1A1GAAMAPTTP53 | |
| SCHEMBL14939857 | 0.86 | NPSR1 (0.48) | NPSR1ALDH1A1GAAMAPTTP53 | |
| SCHEMBL14939673 | 0.86 | NPSR1 (0.51) | NPSR1ALDH1A1MAPTTP53LMNA | |
| SCHEMBL14939053 | 0.85 | NPSR1 (0.45) | NPSR1ALDH1A1GAAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |