Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939378 | 0.86 | NPSR1 (0.55) | NPSR1KMT2AKDM4ESIGMAR1MAPT | |
| SCHEMBL14939617 | 0.86 | NPSR1 (1.00) | NPSR1MMP2MMP9SIGMAR1MAPT | |
| SCHEMBL14938922 | 0.85 | NPSR1 (0.53) | NPSR1KMT2AMMP2MMP9ADAM17 | |
| SCHEMBL14938942 | 0.84 | NPSR1 (0.53) | NPSR1KMT2AKDM4E | |
| SCHEMBL14939774 | 0.84 | NPSR1 (0.52) | NPSR1KMT2AKDM4EDRD4MAPT | |
| SCHEMBL14939425 | 0.83 | NPSR1 (0.79) | NPSR1MMP2MMP9KDM4ENPC1 | |
| SCHEMBL14940280 | 0.82 | NPSR1 (0.70) | NPSR1KMT2AMMP2MMP9SIGMAR1 | |
| SCHEMBL14939533 | 0.82 | NPSR1 (0.73) | NPSR1KMT2AMMP2MMP9KDM4E | |
| SCHEMBL14939178 | 0.82 | NPSR1 (0.77) | NPSR1MMP2MMP9SIGMAR1MAPT | |
| SCHEMBL14939709 | 0.82 | NPSR1 (0.77) | NPSR1MMP2MMP9SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |