Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939879 | 0.89 | NPSR1 (0.53) | NPSR1MMP2MMP9ADAM17MAPT | |
| SCHEMBL14939502 | 0.87 | NPSR1 (0.52) | NPSR1MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL14939533 | 0.86 | NPSR1 (0.73) | NPSR1MMP2MMP9ADAM17MAPT | |
| SCHEMBL14939117 | 0.86 | NPSR1 (0.50) | NPSR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14940461 | 0.84 | NPSR1 (0.62) | NPSR1MMP2MMP9MAPTTSHR | |
| SCHEMBL14939280 | 0.83 | NPSR1 (0.76) | NPSR1MMP2MMP9MAPTTSHR | |
| SCHEMBL14938994 | 0.83 | NPSR1 (0.47) | NPSR1MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL14939617 | 0.83 | NPSR1 (1.00) | NPSR1MMP2MMP9MAPTSIGMAR1 | |
| SCHEMBL14939647 | 0.82 | NPSR1 (0.74) | NPSR1MMP2MMP9ADAM17MAPT | |
| SCHEMBL14940278 | 0.82 | NPSR1 (0.67) | NPSR1MMP2MMP9ADAM17MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |