Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939383 | 0.88 | MAPT (0.58) | MEN1KMT2ANPSR1MAPTTP53 | |
| SCHEMBL14939450 | 0.88 | NPSR1 (0.52) | MEN1KMT2ANPSR1MAPTTP53 | |
| SCHEMBL14938922 | 0.87 | NPSR1 (0.53) | MEN1KMT2ANPSR1MAPTTP53 | |
| SCHEMBL14939174 | 0.87 | NPSR1 (0.65) | MEN1KMT2ANPSR1MAPTALDH1A1 | |
| SCHEMBL14939774 | 0.86 | NPSR1 (0.52) | MEN1KMT2ANPSR1MAPTTP53 | |
| SCHEMBL14938994 | 0.86 | NPSR1 (0.47) | MEN1KMT2ANPSR1HTR1ADRD2 | |
| SCHEMBL14940519 | 0.86 | NPSR1 (0.47) | MEN1KMT2ANPSR1HTR1ADRD2 | |
| SCHEMBL14939760 | 0.85 | NPSR1 (0.49) | MEN1KMT2ANPSR1HTR1ADRD2 | |
| SCHEMBL14939609 | 0.85 | NPSR1 (0.52) | MEN1KMT2ANPSR1HTR1ADRD2 | |
| SCHEMBL14940311 | 0.84 | NPSR1 (0.51) | MEN1KMT2ANPSR1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |