Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940079 | 0.86 | SIGMAR1 (0.50) | NPSR1HTR1AALDH1A1KDM4EACHE | |
| SCHEMBL14939310 | 0.86 | NPSR1 (0.46) | NPSR1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14939088 | 0.85 | NPSR1 (0.46) | NPSR1HTR1AALDH1A1KDM4ELMNA | |
| SCHEMBL14939248 | 0.84 | L3MBTL1 (0.53) | HTR1AALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL14939152 | 0.84 | KDM4E (0.44) | NPSR1HTR1AHTR7ALDH1A1KDM4E | |
| SCHEMBL14938920 | 0.82 | SIGMAR1 (0.43) | NPSR1ALDH1A1KDM4ESIGMAR1MMP2 | |
| SCHEMBL14939412 | 0.80 | NPSR1 (0.70) | NPSR1HTR1ASIGMAR1MMP2MMP9 | |
| SCHEMBL14939887 | 0.78 | NPSR1 (0.64) | NPSR1ALDH1A1KDM4ELMNAADAM17 | |
| SCHEMBL14939617 | 0.78 | NPSR1 (1.00) | NPSR1LMNAMAPTSIGMAR1MMP2 | |
| SCHEMBL14939558 | 0.77 | NPSR1 (0.62) | NPSR1ALDH1A1LMNASMN1; SMN2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |