Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939481 | 0.87 | NPSR1 (0.46) | NPSR1ADAM17TSHRLMNAMAPT | |
| SCHEMBL14939558 | 0.84 | NPSR1 (0.62) | NPSR1ADAM17TSHRHTTLMNA | |
| SCHEMBL14939729 | 0.83 | NPSR1 (0.68) | NPSR1ADAM17TSHRHTTLMNA | |
| SCHEMBL14939843 | 0.82 | NPSR1 (0.42) | NPSR1ADAM17HTTLMNAMAPT | |
| SCHEMBL14939259 | 0.81 | NPSR1 (0.65) | NPSR1ADAM17TSHRHTTLMNA | |
| SCHEMBL14939533 | 0.81 | NPSR1 (0.73) | NPSR1ADAM17TSHRHTTLMNA | |
| SCHEMBL14939412 | 0.80 | NPSR1 (0.70) | NPSR1MMP2MMP9SIGMAR1DRD2 | |
| SCHEMBL14940011 | 0.80 | NPSR1 (0.66) | NPSR1ADAM17TSHRHTTLMNA | |
| SCHEMBL14939280 | 0.79 | NPSR1 (0.76) | NPSR1TSHRLMNAPOLBMAPT | |
| SCHEMBL14940278 | 0.78 | NPSR1 (0.67) | NPSR1ADAM17TSHRHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |