Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939942 | 0.90 | NPSR1 (0.68) | NPSR1ALDH1A1MAPTLMNAMMP2 | |
| SCHEMBL14940325 | 0.87 | NPSR1 (0.64) | NPSR1ALDH1A1HTTMAPTSIGMAR1 | |
| SCHEMBL14939954 | 0.86 | NPSR1 (0.82) | NPSR1MAPTSIGMAR1LMNAMMP2 | |
| SCHEMBL14939947 | 0.86 | NPSR1 (0.77) | NPSR1ALDH1A1MAPTSIGMAR1LMNA | |
| SCHEMBL14938987 | 0.85 | NPSR1 (0.85) | NPSR1MAPTSIGMAR1LMNAMMP2 | |
| SCHEMBL14939617 | 0.85 | NPSR1 (1.00) | NPSR1MAPTSIGMAR1LMNAMMP2 | |
| SCHEMBL14939013 | 0.82 | NPSR1 (0.64) | NPSR1ALDH1A1MAPTSIGMAR1LMNA | |
| SCHEMBL14939920 | 0.81 | NPSR1 (0.70) | NPSR1ALDH1A1HTTMAPTLMNA | |
| SCHEMBL14940217 | 0.81 | NPSR1 (0.82) | NPSR1ALDH1A1HTTMAPTLMNA | |
| SCHEMBL14939435 | 0.81 | NPSR1 (0.77) | NPSR1ALDH1A1HTTMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |