Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048546 | 0.81 | MAPT (0.62) | KMT2AMEN1MAPTMAPK1KDM4E | |
| SCHEMBL14939315 | 0.81 | MEN1 (0.63) | KMT2AMEN1MAPTMAPK1KDM4E | |
| SCHEMBL21048499 | 0.73 | MAPT (0.42) | KMT2AMEN1MAPTMAPK1KDM4E | |
| SCHEMBL14939987 | 0.68 | RAB9A (0.54) | KMT2AMEN1MAPTKDM4ECYP19A1 | |
| SCHEMBL14939531 | 0.67 | RAB9A (0.58) | KMT2AMEN1MAPTMAPK1KDM4E | |
| SCHEMBL14938913 | 0.67 | MEN1 (0.68) | KMT2AMEN1MAPTMAPK1KDM4E | |
| SCHEMBL28946044 | 0.65 | CYP19A1 (0.43) | KMT2AMEN1MAPTCYP19A1HTR2B | |
| SCHEMBL18462364 | 0.64 | PTPRC (0.65) | KMT2AMEN1MAPTGAATDP2 | |
| SCHEMBL2187789 | 0.64 | ADORA1 (0.55) | KMT2AMAPTKDM4ERAB9ANPC1 | |
| SCHEMBL14939560 | 0.64 | RAB9A (0.61) | KMT2AMEN1MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |