SCHEMBL14940332

SCHEMBL14940332

Cc1ccccc1CN1CCN(C2(c3cccc(F)c3)Cc3c(F)cccc3C2=O)CC1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
GAA P10253 2/20 0.47
KDM4E B2RXH2 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
KMT2A Q03164 1/20 0.39
CHRM1 P11229 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
GNRHR P30968 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
NPSR1 Q6W5P4 2/20 0.36
ATM Q13315 1/20 0.36
CLPP Q16740 1/20 0.36
CYP2A13 Q16696 1/20 0.36
ALDH3A1 P30838 1/20 0.35
RAB9A P51151 1/20 0.35
HTR6 P50406 1/20 0.35
LMNA P02545 1/20 0.35
ACHE P22303 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939127 0.93 ALDH1A1 (0.40) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14939125 0.93 ALDH1A1 (0.40) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14939319 0.93 ALDH1A1 (0.40) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14938818 0.93 ALDH1A1 (0.38) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14939231 0.92 KMT2A (0.41) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14939212 0.91 ALDH1A1 (0.37) ALDH1A1GAAKDM4EKMT2ASIGMAR1
SCHEMBL14940179 0.91 ALDH1A1 (0.37) ALDH1A1GAATDP1CHRM1L3MBTL1
SCHEMBL14939181 0.91 ALDH1A1 (0.41) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14938829 0.90 ALDH1A1 (0.41) ALDH1A1GAAKDM4ETDP1KMT2A
SCHEMBL14939079 0.89 ALDH1A1 (0.49) ALDH1A1GAAKDM4ETDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO claimed
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed