Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939148 | 0.81 | TP53 (0.58) | HTR2BTP53MAPTLMNAMAPK1 | |
| Fluindarol SCHEMBL2110111 | 0.80 | MAPT (0.61) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL14939515 | 0.79 | RAB9A (0.49) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL14665736 | 0.79 | HTR2C (0.47) | HTR2BMAPK1HTR2CHTR2ATSHR | |
| SCHEMBL14940009 | 0.77 | MAPT (0.61) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL11540712 | 0.73 | ALDH1A1 (0.61) | MAPTLMNAHTR2CGAANPSR1 | |
| SCHEMBL8957963 | 0.73 | MEN1 (0.63) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL4573093 | 0.73 | MEN1 (0.68) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL14939315 | 0.73 | MEN1 (0.63) | HTR2BTP53MAPTLMNAMAPK1 | |
| SCHEMBL14939598 | 0.73 | RAB9A (0.63) | HTR2BTP53MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |