Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12351497 | 0.82 | SMN1; SMN2 (0.46) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2139183 | 0.81 | MEN1 (0.49) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16266653 | 0.72 | MEN1 (0.44) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9533470 | 0.71 | KMT2A (0.77) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22048013 | 0.70 | KMT2A (0.65) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28708297 | 0.69 | MEN1 (0.56) | KMT2AMEN1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL22084261 | 0.69 | MEN1 (0.56) | KMT2AMEN1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL21817022 | 0.68 | RAB9A (1.00) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5637621 | 0.68 | KMT2A (0.73) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL42716 | 0.68 | RAB9A (1.00) | MAPTNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |