SCHEMBL14940754

SCHEMBL14940754

COc1cc2nc(N3CCN(C)CC3)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 19/20 1.00
NSD2 O96028 3/20 1.00
NSD3 Q9BZ95 3/20 1.00
EHMT1 Q9H9B1 3/20 1.00
EZH2 Q15910 1/20 1.00
NPC1 O15118 1/20 0.93
KDM1A O60341 1/20 0.93
MTOR P42345 1/20 0.93
RAB9A P51151 1/20 0.93
DNMT3A Q9Y6K1 1/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29351415 0.97 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
SCHEMBL366593 0.97 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
Hydrochloric Acid SCHEMBL2595237 0.96 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
Hydrochloric Acid SCHEMBL20535174 0.96 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
Hydrochloric Acid SCHEMBL29849313 0.96 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
Water SCHEMBL21610936 0.96 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1EZH2
Hydrochloric Acid SCHEMBL15668608 0.95 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1EZH2
SCHEMBL15280252 0.95 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1EZH2
SCHEMBL20016196 0.93 DNMT3A (1.00) EHMT2NSD2NSD3EHMT1EZH2
SCHEMBL15280410 0.93 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1EZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-09-17 US claimed
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) 2014-10-02 US claimed
WO-2014074517-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2014-05-15 WO claimed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
EP-2828250-B1 QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY IMPERIAL COLLEGE INNOVATIONS LTD (GB) 2021-03-10 EP disclosed
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) 2014-10-02 US disclosed
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) 2014-10-02 US disclosed
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) 2014-10-02 US disclosed
WO-2014074517-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2014-05-15 WO disclosed
WO-2014074517-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2014-05-15 WO disclosed
WO-2013140148-A1 QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY IMPERIAL INNOVATIONS LIMITED (GB) 2013-09-26 WO disclosed
WO-2013140148-A1 QUINAZOLINE COMPOUNDS AND THEIR USE IN THERAPY IMPERIAL INNOVATIONS LIMITED (GB) 2013-09-26 WO disclosed
WO-2013070852-A2 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2013-05-16 WO disclosed
WO-2013070852-A2 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2013-05-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 EHMT2 2235/4885NSD2 3229/4885NSD3 2277/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EHMT2 624/4885NSD2 3370/4885NSD3 1872/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 EHMT2 624/4885NSD2 3370/4885NSD3 1872/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 EHMT2 751/4885NSD2 1122/4885NSD3 1478/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN EHMT2 2637/4885NSD2 3404/4885NSD3 2018/4885
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO BMI1, DNMT3L, DNMT3B EHMT2 8/4885NSD2 265/4885NSD3 94/4885
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO BMI1, DNMT1, DNMT3A EHMT2 8/4885NSD2 1028/4885NSD3 277/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF EHMT2 691/4885NSD2 2084/4885NSD3 1313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.