SCHEMBL366593

SCHEMBL366593

COc1cc2nc(N3CCCN(C)CC3)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 19/20 1.00
NSD2 O96028 3/20 1.00
NSD3 Q9BZ95 3/20 1.00
EHMT1 Q9H9B1 3/20 1.00
NPC1 O15118 1/20 1.00
KDM1A O60341 1/20 1.00
MTOR P42345 1/20 1.00
RAB9A P51151 1/20 1.00
EZH2 Q15910 1/20 0.93
DNMT3A Q9Y6K1 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29351415 1.00 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1NPC1
Water SCHEMBL21610936 0.99 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1NPC1
Hydrochloric Acid SCHEMBL20535174 0.99 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1NPC1
Hydrochloric Acid SCHEMBL2595237 0.99 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1NPC1
Hydrochloric Acid SCHEMBL29849313 0.99 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1NPC1
Hydrochloric Acid SCHEMBL15668608 0.98 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1NPC1
SCHEMBL14940754 0.97 EHMT2 (1.00) EHMT2NSD2NSD3EHMT1NPC1
SCHEMBL15280407 0.95 EHMT2 (0.94) EHMT2NSD2NSD3EHMT1NPC1
SCHEMBL21593815 0.94 EHMT2 (0.88) EHMT2NSD2NSD3EHMT1NPC1
SCHEMBL15280410 0.93 EHMT2 (0.98) EHMT2NSD2NSD3EHMT1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 243 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250160275-A1 COMPOUNDS FOR MODIFYING MEIOTIC RECOMBINATION AND METHODS RELATING THERETO THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2025-05-22 US claimed
WO-2024211130-A1 METHODS FOR MODIFYING MEIOTIC RECOMBINATION IN PLANTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2024-10-10 WO claimed
US-20230364153-A1 METHOD FOR DIRECT REPROGRAMMING FROM SOMATIC CELLS INTO PANCREATIC BETA CELLS BY USING MICRORNA, AND DIFFERENTIATION COMPOSITION Research & Business Foundation Sungkyunkwan University (KR) 2023-11-16 US claimed
WO-2023164606-A1 COMPOUNDS FOR MODIFYING MEIOTIC RECOMBINATION AND METHODS RELATING THERETO THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2023-08-31 WO claimed
US-20230218631-A1 G9A INHIBITION DECREASES STRESS-INDUCED AND DEPENDENCE-INDUCED ESCALATION OF ALCOHOL DRINKING MUSC FOUND FOR RES DEV (US) 2023-07-13 US claimed
WO-2022229932-A1 HYPOXIA INDUCIBLE FACTOR (HIF) INHIBITORS FOR TREATMENT OF ATROPHY ASSOCIATED WITH RETINAL HYPOXIA STEFANSSON EINAR (IS) 2022-11-03 WO claimed
WO-2022065859-A1 METHOD FOR DIRECT REPROGRAMMING FROM SOMATIC CELLS INTO PANCREATIC BETA CELLS BY USING MICRORNA, AND DIFFERENTIATION COMPOSITION 성균관대학교산학협력단 2022-03-31 WO claimed
WO-2022016097-A1 G9A INHIBITION DECREASES STRESS-INDUCED AND DEPENDENCE-INDUCED ESCALATION OF ALCOHOL DRINKING MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2022-01-20 WO claimed
US-20210213014-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES Epizyme, Inc. 2021-07-15 US claimed
US-20210198277-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS Epizyme, Inc. 2021-07-01 US claimed
US-20200054635-A1 COMBINATION THERAPIES WITH EHMT2 INHIBITORS Epizyme, Inc. 2020-02-20 US claimed
CN-110621316-A Combination therapy with EHMT2 inhibitors EPIZYME股份有限公司 2019-12-27 CN claimed
EP-3442947-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS Epizyme Inc (US) 2019-02-20 EP claimed
WO-2018195450-A1 COMBINATION THERAPIES WITH EHMT2 INHIBITORS Epizyme, Inc. (US) 2018-10-25 WO claimed
US-20170355712-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS Epizyme, Inc. 2017-12-14 US claimed
WO-2017181177-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS Epizyme, Inc. (US) 2017-10-19 WO claimed
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-09-17 US claimed
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO ISTITUTO PASTEUR - FONDAZIONE CENCI BOLOGNETTI (IT) 2014-10-02 US claimed
WO-2014074517-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2014-05-15 WO claimed
WO-2013070852-A2 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2013-05-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355712-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS SHMT1, BHMT, BHMT2 EHMT2 4/4885NSD2 136/4885NSD3 121/4885
US-20210198277-A1 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS SHMT1, BHMT, BHMT2 EHMT2 4/4885NSD2 136/4885NSD3 121/4885
US-20230218631-A1 G9A INHIBITION DECREASES STRESS-INDUCED AND DEPENDENCE-INDUCED ESCALATION OF ALCOHOL DRINKING EHMT2, EHMT1, KMT2A EHMT2 1/4885NSD2 160/4885NSD3 76/4885
US-20200054635-A1 COMBINATION THERAPIES WITH EHMT2 INHIBITORS EHMT2, BHMT, SHMT2 EHMT2 1/4885NSD2 144/4885NSD3 312/4885
US-20140294764-A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO BMI1, DNMT3L, DNMT3B EHMT2 8/4885NSD2 265/4885NSD3 94/4885
US-20150259649-A1 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO BMI1, DNMT1, DNMT3A EHMT2 8/4885NSD2 1028/4885NSD3 277/4885
US-20210213014-A1 METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES EHMT2, BHMT2, BHMT EHMT2 1/4885NSD2 449/4885NSD3 727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.