Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.90 |
| ▸ | TPO | P07202 | 1/20 | 0.90 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CBX7 | O95931 | 1/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-06282999 SCHEMBL14936135 | 0.95 | MPO (1.00) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL29616404 | 0.94 | MPO (1.00) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL14936647 | 0.94 | MPO (1.00) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL14936089 | 0.87 | MPO (0.84) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL14937052 | 0.86 | MPO (1.00) | MPOTPOGAAMAPK1ALDH1A1 | |
| SCHEMBL14936542 | 0.84 | MPO (0.81) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL15366292 | 0.84 | MPO (0.80) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL14947169 | 0.84 | MPO (0.81) | MPOTPOGAAMAPK1MEN1 | |
| SCHEMBL14936343 | 0.83 | MPO (0.78) | MPOTPOGAAMAPK1HPGD | |
| SCHEMBL14936736 | 0.83 | MPO (0.80) | MPOTPOGAAMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776405-A1 | 2-THIOPYRIMIDINONES | Pfizer Inc (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013068875-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2013-05-16 | — | — | WO | disclosed |