Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138469 | 0.84 | MAPT (0.56) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL11339768 | 0.80 | USP2 (0.51) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL11800602 | 0.78 | MAPT (0.51) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL23735965 | 0.77 | MAPT (0.50) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL22328919 | 0.77 | MAPT (0.50) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL22110976 | 0.77 | MAPT (0.50) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL8806385 | 0.75 | PKM (0.53) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL30274855 | 0.74 | ALOX5 (0.54) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL6218112 | 0.74 | PKM (0.51) | POLBPKMMAPTNPC1RAB9A | |
| SCHEMBL21174509 | 0.73 | MAPT (0.50) | POLBPKMMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |