Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24630698 | 0.80 | PDK1 (0.51) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL1700062 | 0.80 | PDK1 (0.51) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL21369290 | 0.80 | PDK1 (0.51) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL24801874 | 0.80 | PDK1 (0.51) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL17778486 | 0.80 | PDK1 (0.51) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL3427686 | 0.78 | PDK1 (0.46) | PDK1PDK2PDK3SPHK1L3MBTL1 | |
| SCHEMBL28127144 | 0.77 | PDK1 (0.49) | PDK1PDK2PDK3 | |
| SCHEMBL28189410 | 0.77 | PDK1 (0.49) | PDK1PDK2PDK3 | |
| SCHEMBL3427689 | 0.77 | PDK1 (0.49) | PDK1PDK2PDK3SPHK1 | |
| SCHEMBL28153185 | 0.77 | PDK1 (0.49) | PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597089-A1 | Tricyclic heterocyclic compounds | Bristol-Myers Squibb Company (US) | 2013-05-29 | — | — | EP | disclosed |
| EP-2592071-A1 | Tricyclic heterocyclic compounds | Bristol-Myers Squibb Company (US) | 2013-05-15 | — | — | EP | disclosed |