Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877314 | 0.94 | HDAC6 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL12820248 | 0.84 | HDAC1 (0.41) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL6921380 | 0.80 | HTR6 (0.36) | HDAC1HDAC6HTR6 | |
| SCHEMBL1120477 | 0.78 | HDAC1 (0.45) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL13293713 | 0.78 | HDAC1 (0.42) | HDAC1HDAC6HTR5AHTR6BAZ2B | |
| Hydrochloric Acid SCHEMBL1120519 | 0.78 | HDAC1 (0.44) | HDAC1HDAC6HTR5AHTR6BAZ2B | |
| SCHEMBL170011 | 0.77 | HTR6 (0.49) | HDAC1HDAC6HTR5AHTR6HRH1 | |
| SCHEMBL12819815 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL1120692 | 0.75 | BAZ2B (0.50) | HDAC1HDAC6HTR6BAZ2B | |
| SCHEMBL13293472 | 0.74 | HDAC1 (0.43) | HDAC1HDAC6HTR5AHTR6BAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137705-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2013-05-30 | — | — | US | disclosed |
| US-20130137705-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2013-05-30 | — | — | US | disclosed |
| US-20130123277-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123277-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123277-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | HTR3B, HTR2C, HTR4 | HDAC1 4369/4885HDAC6 3579/4885HDAC8 3544/4885 |
| US-20130137705-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | HTR3B, HTR4, HTR2C | HDAC1 4373/4885HDAC6 3551/4885HDAC8 3599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.