Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | PRKCG | P05129 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MARK3 | P27448 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494600 | 0.86 | DGAT1 (0.33) | DGAT1MAPK10MAPTPLK4CHEK1 | |
| SCHEMBL1494642 | 0.84 | CYP2D6 (0.34) | DGAT1MAPTGSK3BMAPK14 | |
| SCHEMBL1494633 | 0.82 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL1494638 | 0.82 | MAPK10 (0.31) | DGAT1MAPK10MAPTPLK4CHEK1 | |
| SCHEMBL1494656 | 0.77 | ALOX5AP (0.33) | MAPK10PLK4CHEK1MAPK13DAPK3 | |
| SCHEMBL1494588 | 0.75 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL6526498 | 0.73 | MAPK14 (0.35) | DGAT1MAPK10MAPTMAPK13CDK1 | |
| SCHEMBL6521486 | 0.72 | MAPT (0.34) | DGAT1MAPTMAPK14 | |
| SCHEMBL87554 | 0.71 | DGAT1 (0.34) | DGAT1MAPT | |
| SCHEMBL1494466 | 0.71 | MAPT (0.31) | DGAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |