Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526484 | 0.88 | DGAT1 (0.30) | DGAT1 | |
| SCHEMBL1494537 | 0.82 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL1494642 | 0.79 | CYP2D6 (0.34) | DGAT1 | |
| SCHEMBL1494698 | 0.73 | BRAF (0.37) | — | |
| SCHEMBL1494588 | 0.70 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL6526498 | 0.69 | MAPK14 (0.35) | DGAT1 | |
| SCHEMBL1494600 | 0.69 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL6521486 | 0.68 | MAPT (0.34) | DGAT1 | |
| SCHEMBL6520486 | 0.67 | BRAF (0.38) | — | |
| SCHEMBL6518143 | 0.67 | BRAF (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |