SCHEMBL14948265

SCHEMBL14948265

c1ccc([Si](c2ccccc2)(c2cccc(-c3cccc4c3oc3ccccc34)c2)c2ccc3c4ccccc4c4ccccc4c3c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.51
GGPS1 O95749 1/20 0.44
PRKDC P78527 8/20 0.41
PTGES2 Q9H7Z7 1/20 0.41
ATM Q13315 1/20 0.37
PRMT5 O14744 1/20 0.36
WDR77 Q9BQA1 1/20 0.36
MEN1 O00255 1/20 0.35
CSF1R P07333 1/20 0.35
PDGFRB P09619 1/20 0.35
MAPT P10636 1/20 0.35
KIT P10721 1/20 0.35
FLT3 P36888 1/20 0.35
KMT2A Q03164 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
CDC14B O60729 1/20 0.35
CDC14A Q9UNH5 1/20 0.35
PIK3CD O00329 3/20 0.35
PIK3CB P42338 3/20 0.35
TP53 P04637 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13681137 0.93 ALOX5 (0.57) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL13681141 0.91 ALOX5 (0.55) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL17090662 0.88 ALOX5 (0.40) ALOX5GGPS1PRKDCPTGES2CYP1A2
SCHEMBL13681150 0.88 ALOX5 (0.52) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL24604379 0.88 ALOX5 (0.51) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL14058202 0.86 ALOX5 (0.50) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL15374772 0.85 ALOX5 (0.54) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL13681151 0.85 ALOX5 (0.56) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL13681153 0.84 ALOX5 (0.50) ALOX5GGPS1PRKDCPTGES2ATM
SCHEMBL14056399 0.84 ALOX5 (0.48) ALOX5GGPS1PRKDCPTGES2ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS OCIAD2, OCIAD1, YAP1 ALOX5 738/4885GGPS1 497/4885PRKDC 3327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.