SCHEMBL14948266

SCHEMBL14948266

c1ccc([Si](c2ccccc2)(c2cccc(-c3cccc4c3sc3ccccc34)c2)c2ccc3c4ccccc4c4ccccc4c3c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.51
PRKDC P78527 8/20 0.39
PARP14 Q460N5 1/20 0.37
TNKS O95271 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36
F9 P00740 1/20 0.36
LIMK1 P53667 2/20 0.35
MAPT P10636 2/20 0.33
DNPH1 O43598 1/20 0.33
PIK3CD O00329 2/20 0.33
PIK3CB P42338 2/20 0.33
BRD4 O60885 1/20 0.33
PIK3CA P42336 1/20 0.33
MTOR P42345 1/20 0.33
PIK3CG P48736 1/20 0.33
KCNH2 Q12809 1/20 0.33
BRDT Q58F21 1/20 0.33
GPR3 P46089 1/20 0.33
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17754637 1.00 ALOX5 (0.51) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL17754638 0.95 ALOX5 (0.56) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL126275 0.93 ALOX5 (0.57) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL29306737 0.93 ALOX5 (0.57) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL17754641 0.92 ALOX5 (0.51) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL17754643 0.92 ALOX5 (0.57) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL13681155 0.91 ALOX5 (0.55) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL17754685 0.90 ALOX5 (0.43) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL14948290 0.88 ALOX5 (0.40) ALOX5PRKDCPARP14TNKSTNKS2
SCHEMBL13681149 0.88 ALOX5 (0.52) ALOX5PRKDCPARP14TNKSTNKS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS OCIAD2, OCIAD1, YAP1 ALOX5 738/4885PRKDC 3327/4885PARP14 2297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.