Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750427 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL14948684 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL14945585 | 0.87 | ACACB (0.41) | ACACBKAT2BBAZ2BACACA | |
| SCHEMBL14945397 | 0.85 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL29700513 | 0.85 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL29642175 | 0.85 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL21816549 | 0.85 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL14945398 | 0.85 | ACACB (0.47) | ACACBACACA | |
| SCHEMBL18137727 | 0.84 | ACACB (0.39) | ACACBKAT2BBAZ2BACACA | |
| SCHEMBL21876832 | 0.83 | ACACA (0.47) | ACACBKAT2BBAZ2BACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110431144-B | Cyano-substituted heteroaryl pyrimidone derivatives, and preparation method and application thereof | 浙江海正药业股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| US-11142531-B2 | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| US-11142531-B2 | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| US-20200102322-A1 | CYANO SUBSTITUTED HETEROARYLPYRIMIDINONE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2020-04-02 | — | — | US | disclosed |
| US-20200102322-A1 | CYANO SUBSTITUTED HETEROARYLPYRIMIDINONE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2020-04-02 | — | — | US | disclosed |
| CN-110431144-A | The heteroaryl hepyramine analog derivative and its preparation method and application that cyano replaces | ZHEJIANG HISUN PHARM CO LTD | 2019-11-08 | — | — | CN | disclosed |
| US-20160297834-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC | 2016-10-13 | — | — | US | disclosed |
| US-20150203510-A1 | ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC | 2015-07-23 | — | — | US | disclosed |
| US-8969557-B2 | ACC inhibitors and uses thereof | Nimbus Apollo, Inc. (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130123231-A1 | ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2013071169-A1 | ACC INHIBITORS AND USES THEREOF | Nimbus Apollo, Inc. (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200102322-A1 | CYANO SUBSTITUTED HETEROARYLPYRIMIDINONE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | ACACA, COASY, ACACB | PDE4D 3031/4885PDE4A 2846/4885PDE4B 3044/4885 |
| US-20150203510-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | PDE4D 3100/4885PDE4A 2812/4885PDE4B 2888/4885 |
| US-11142531-B2 | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof | ACACA, COASY, ACACB | PDE4D 3031/4885PDE4A 2846/4885PDE4B 3044/4885 |
| US-20130123231-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | PDE4D 3100/4885PDE4A 2812/4885PDE4B 2888/4885 |
| US-20160297834-A1 | ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | PDE4D 3100/4885PDE4A 2812/4885PDE4B 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.