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SCHEMBL14949291

SCHEMBL14949291

COCCOc1nc(N)cc(Oc2ccc(-c3nnc(Nc4cccc(C)c4)[nH]3)cc2)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KIT P10721 2/20 0.38
▸ FLT3 P36888 2/20 0.38
▸ PDGFRB P09619 1/20 0.38
▸ PDGFRA P16234 1/20 0.38
▸ CDK11B P21127 1/20 0.38
▸ CDKL2 Q92772 1/20 0.38
▸ SYK P43405 5/20 0.35
▸ AURKB Q96GD4 1/20 0.35
▸ KDR P35968 3/20 0.34
▸ EGFR P00533 1/20 0.33
▸ CSF1R P07333 1/20 0.33
▸ CDK8 P49336 2/20 0.33
▸ TP53 P04637 3/20 0.32
▸ MAPT P10636 3/20 0.32
▸ TLR7 Q9NYK1 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ RXFP1 Q9HBX9 1/20 0.31
▸ SCN2A Q99250 1/20 0.30
▸ SCN10A Q9Y5Y9 1/20 0.30
▸ LOXL2 Q9Y4K0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949363 0.92 SYK (0.34) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949266 0.91 PDGFRB (0.40) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949696 0.89 PDGFRB (0.41) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL12336281 0.89 PDGFRB (0.51) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949260 0.88 KIT (0.37) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL16786018 0.87 CDK8 (0.35) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949258 0.85 PDGFRB (0.43) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949295 0.84 POLB (0.42) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949274 0.83 PDGFRB (0.41) KITFLT3PDGFRBPDGFRACDK11B
SCHEMBL14949356 0.83 CDK8 (0.34) KITFLT3PDGFRBPDGFRACDK11B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KIT 540/4885FLT3 303/4885PDGFRB 497/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KIT 540/4885FLT3 303/4885PDGFRB 497/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KIT 540/4885FLT3 303/4885PDGFRB 497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.