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SCHEMBL14949295

SCHEMBL14949295

COCCOCCSc1nc(N)cc(Oc2ccc(-c3nnc(Nc4cccc(C)c4)[nH]3)cc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ PDGFRB P09619 1/20 0.42
▸ KIT P10721 1/20 0.42
▸ PDGFRA P16234 1/20 0.42
▸ CDK11B P21127 1/20 0.42
▸ FLT3 P36888 1/20 0.42
▸ CDKL2 Q92772 1/20 0.42
▸ MAPK1 P28482 1/20 0.37
▸ NPC1 O15118 4/20 0.36
▸ RAB9A P51151 4/20 0.36
▸ LMNA P02545 4/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ P2RY12 Q9H244 1/20 0.34
▸ EGFR P00533 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949269 0.91 PDGFRB (0.47) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL12336263 0.90 PDGFRB (0.54) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL14949275 0.88 PDGFRB (0.44) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL14949273 0.85 PDGFRB (0.41) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL12336289 0.84 PDGFRB (0.56) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL14949291 0.84 KIT (0.38) POLBPDGFRBKITPDGFRACDK11B
SCHEMBL14949284 0.83 RXRA (0.46) POLBPDGFRBKITPDGFRACDK11B
SCHEMBL14949276 0.82 PDGFRB (0.48) POLBTDP1PDGFRBKITPDGFRA
SCHEMBL14949258 0.81 PDGFRB (0.43) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL14949260 0.81 KIT (0.37) PDGFRBKITPDGFRACDK11BFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 POLB 2904/4885TDP1 1948/4885PDGFRB 497/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 POLB 2904/4885TDP1 1948/4885PDGFRB 497/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 POLB 2904/4885TDP1 1948/4885PDGFRB 497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.