Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949359

SCHEMBL14949359

SCHEMBL14949359

COCCOc1cc(Oc2cccc(-c3nnc(Nc4cccc(C)c4)[nH]3)c2)nc(N)n1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 2/20 0.35
▸ KIT P10721 1/20 0.35
▸ FLT3 P36888 1/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ NOD1 Q9Y239 1/20 0.34
▸ SYK P43405 4/20 0.33
▸ LOXL2 Q9Y4K0 1/20 0.33
▸ GSK3B P49841 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ CHEK1 O14757 1/20 0.32
▸ CHEK2 O96017 1/20 0.32
▸ AURKB Q96GD4 1/20 0.32
▸ CDK8 P49336 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ MAP4K4 O95819 1/20 0.32
▸ ROCK2 O75116 1/20 0.32
▸ PRKACA P17612 1/20 0.32
▸ PRKCD Q05655 1/20 0.32
▸ ROCK1 Q13464 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949260 0.92 KIT (0.37) KDRKITFLT3NPC1RAB9A
SCHEMBL14949331 0.90 RAB9A (0.39) NPC1RAB9ANOD1SYKMAPT
SCHEMBL12336528 0.88 PDGFRB (0.40) KDRKITFLT3MAPTEGFR
SCHEMBL14949363 0.88 SYK (0.34) KDRKITFLT3SYKLOXL2
SCHEMBL14949332 0.86 RAB9A (0.38) NPC1RAB9ANOD1MAPTCDK8
SCHEMBL14949316 0.86 RAB9A (0.36) KDRKITFLT3NPC1RAB9A
SCHEMBL14949368 0.85 RAB9A (0.36) KDRNPC1RAB9ANOD1MAPT
SCHEMBL14949375 0.84 GSK3B (0.37) KDRFLT3SYKGSK3BMAPT
SCHEMBL14949309 0.84 ROCK1 (0.40) KDRKITNPC1RAB9ANOD1
SCHEMBL14949247 0.82 RAB9A (0.37) KDRKITFLT3NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KDR 533/4885KIT 540/4885FLT3 303/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885KIT 540/4885FLT3 303/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885KIT 540/4885FLT3 303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.