Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949247

SCHEMBL14949247

SCHEMBL14949247

CCOc1cc(Oc2ccc(-c3nnc(Nc4cccc(C)c4)[nH]3)cc2)nc(N)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 5/20 0.37
▸ NPC1 O15118 4/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.36
▸ NOD1 Q9Y239 1/20 0.36
▸ SCN2A Q99250 1/20 0.36
▸ SCN10A Q9Y5Y9 1/20 0.36
▸ PDGFRB P09619 1/20 0.35
▸ KIT P10721 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ CDK11B P21127 1/20 0.35
▸ FLT3 P36888 1/20 0.35
▸ CDKL2 Q92772 1/20 0.35
▸ NUDT1 P36639 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ RECQL P46063 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ MAPT P10636 3/20 0.34
▸ TP53 P04637 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949331 0.92 RAB9A (0.39) RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL14949254 0.92 RAB9A (0.38) RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL14949260 0.90 KIT (0.37) RAB9ANPC1SMN1; SMN2NOD1PDGFRB
SCHEMBL14949279 0.90 PDGFRB (0.37) RAB9ANPC1ALDH1A1SMN1; SMN2NOD1
SCHEMBL14949288 0.89 RAB9A (0.39) RAB9ANPC1ALDH1A1SMN1; SMN2NOD1
SCHEMBL14949248 0.89 SMN1; SMN2 (0.38) RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL14949261 0.89 NPC1 (0.34) RAB9ANPC1SMN1; SMN2NOD1PDGFRB
SCHEMBL14949504 0.88 KDR (0.38) RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2
SCHEMBL16786019 0.88 NUDT1 (0.37) RAB9ANPC1ALDH1A1SMN1; SMN2NOD1
SCHEMBL12336276 0.88 PDGFRB (0.49) ALDH1A1PDGFRBKITPDGFRACDK11B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 RAB9A 1281/4885NPC1 3866/4885ALDH1A1 3693/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 RAB9A 1281/4885NPC1 3866/4885ALDH1A1 3693/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 RAB9A 1281/4885NPC1 3866/4885ALDH1A1 3693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.