Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 19/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284200 | 0.90 | CDK8 (0.58) | CDK8CDK7CDK6 | |
| SCHEMBL3561767 | 0.84 | MAPK14 (0.61) | MAPK14 | |
| SCHEMBL3636740 | 0.83 | CDK8 (0.56) | CDK8CDK7CDK6 | |
| SCHEMBL12892598 | 0.82 | CDK8 (0.54) | CDK8 | |
| SCHEMBL4684136 | 0.82 | PARP10 (0.44) | MAPK14 | |
| SCHEMBL3637169 | 0.82 | CDK8 (0.58) | CDK8CDK7CDK6 | |
| SCHEMBL14949687 | 0.80 | CDK8 (0.40) | CDK8MAPK14 | |
| SCHEMBL14949690 | 0.80 | CDK8 (0.40) | CDK8MAPK14 | |
| SCHEMBL14949675 | 0.77 | CDK8 (0.64) | CDK8CDK7CDK6 | |
| SCHEMBL16037546 | 0.77 | CDK8 (0.52) | CDK8CDK7CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |