Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949687 | 1.00 | CDK8 (0.40) | CDK8KDRMEN1KMT2ARAB9A | |
| SCHEMBL4283781 | 0.91 | LMNA (0.40) | CDK8KDRMEN1KMT2ARAB9A | |
| SCHEMBL4283775 | 0.91 | LMNA (0.40) | CDK8KDRMEN1KMT2ARAB9A | |
| SCHEMBL3642907 | 0.84 | ALDH1A1 (0.41) | CDK8MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3642909 | 0.84 | ALDH1A1 (0.41) | CDK8MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12892597 | 0.83 | NPC1 (0.44) | CDK8RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3641659 | 0.83 | KMT2A (0.40) | CDK8MEN1KMT2ARAB9ALMNA | |
| SCHEMBL3641663 | 0.83 | KMT2A (0.40) | CDK8MEN1KMT2ARAB9ALMNA | |
| SCHEMBL4684027 | 0.81 | MEN1 (0.47) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL4686951 | 0.81 | MEN1 (0.54) | MEN1KMT2ARAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |