Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800900 | 0.90 | TOP2A (0.47) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1457271 | 0.87 | KDM4E (0.45) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1457334 | 0.87 | TOP2A (0.45) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL24879683 | 0.86 | KDM4E (0.44) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL7637380 | 0.86 | KDM4E (0.44) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1456618 | 0.85 | BCHE (0.46) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL8571971 | 0.84 | KDM4E (0.43) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1457309 | 0.78 | ACP1 (0.37) | TOP2AKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6722290 | 0.78 | TOP2A (0.52) | TOP2AKDM4EALDH1A1RAB9AMAPK1 | |
| SCHEMBL20766797 | 0.75 | GAA (0.47) | TOP2AKDM4EALDH1A1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067597-A1 | IMMUNOMODULATORY CONJUGATES | ASCEND BIOPHARMACEUTICALS PTY LTD (AU) | 2013-05-16 | — | — | WO | disclosed |