Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.51 |
| ▸ | MME | P08473 | 15/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875462 | 0.89 | MMEL1 (0.64) | MMEL1MME | |
| SCHEMBL2875456 | 0.89 | MMEL1 (0.64) | MMEL1MME | |
| SCHEMBL12974968 | 0.87 | MMEL1 (0.50) | MMEL1MMEKLKB1KLK1 | |
| SCHEMBL14952828 | 0.82 | MME (0.59) | MMEL1MMEROCK2RPS6KA5RPS6KA4 | |
| SCHEMBL17998322 | 0.76 | CTSA (0.58) | — | |
| SCHEMBL16855111 | 0.75 | MME (0.63) | MMEL1MME | |
| SCHEMBL12317325 | 0.73 | MME (0.61) | MMEL1MME | |
| SCHEMBL18672739 | 0.73 | MME (0.61) | MMEL1MME | |
| SCHEMBL17667998 | 0.73 | MME (0.61) | MMEL1MME | |
| SCHEMBL2875042 | 0.73 | MMEL1 (0.72) | MMEL1MMEROCK2RPS6KA5RPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-B1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |