Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotiam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.99 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.58 |
| ▸ | PGR | P06401 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.51 |
| ▸ | SLC22A8 | Q8TCC7 | 3/20 | 0.51 |
| ▸ | SLC22A11 | Q9NSA0 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotiam SCHEMBL6019446 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL11095123 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL16473046 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL9754126 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL9754124 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL65480 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL11065530 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL27767071 | 0.99 | TDP1 (0.99) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL193845 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL10899868 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9469 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-122080024-A | Cefatigure Synthesis method of An | — | 2026-05-26 | — | — | CN | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-12590108-B2 | Boracic acid compound | PHAENO THERAPEUTICS CO., LTD (CN) | 2026-03-31 | — | — | US | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| US-12529704-B2 | Methods for objective assessment of stress, early detection of risk for stress disorders, matching individuals with treatments, monitoring response to treatment, and new methods of use for drugs | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2026-01-20 | — | — | US | claimed |
| WO-2025237916-A1 | BIOMATERIAL COMPOSITION COMPRISING A POLYHYDROXYBUTYRATE IN PARTICULATE FORM | LABORATOIRES VIVACY (FR) | 2025-11-20 | — | — | WO | claimed |
| US-20250339551-A1 | AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES | HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) | 2025-11-06 | — | — | US | claimed |
| EP-4642492-A1 | AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE FUNCTIONAL SMALL MOLECULE COMPOUNDS FOR ENHANCED TREATMENT OF REFRACTORY DISEASES | Hangzhou Seehe Biotechnology Co., Ltd (CN) | 2025-11-05 | — | — | EP | claimed |
| EP-4642484-A1 | TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE | Hangzhou Seehe Biotechnology Co., Ltd (CN) | 2025-11-05 | — | — | EP | claimed |
| EP-0138523-A1 | Penicillin derivatives and process for preparing the same (11111) | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1985-04-24 | — | — | EP | claimed |
| EP-0026746-B1 | COMBINATORY COMPOSITIONS FOR USE IN A METHOD FOR ENHANCING THE ACTIVITY OF ANTIBIOTICS, ANTIBIOTIC PREPARATIONS HAVING ENHANCED ACTIVITY AND PROCESS FOR THEIR PRODUCTION | CIBA-GEIGY AG (CH) | 1985-04-10 | — | — | EP | claimed |
| US-4503040-A | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors | PFIZER INC. (US) | 1985-03-05 | — | — | US | claimed |
| US-4414204-A | WITH A MURAMYL-PEPTIDE | CIBA-GEIGY CORPORATION (US) | 1983-11-08 | — | — | US | claimed |
| US-4409209-A | POTENTIATION OF ANTIBIOTICS | CIBA-GEIGY CORPORATION (US) | 1983-10-11 | — | — | US | claimed |
| EP-0056560-A1 | Active antibiotic compositions, process for their manufacture and process for the antibiotic activity of antibiotics | CIBA-GEIGY AG (CH) | 1982-07-28 | — | — | EP | claimed |
| EP-0050965-A1 | Beta-lactamase inhibitory composition | Takeda Chemical Industries, Ltd. (JP) | 1982-05-05 | — | — | EP | claimed |
| EP-0004925-B1 | SYNERGISTIC MIXTURES OF ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION | CIBA-GEIGY AG (CH) | 1982-02-24 | — | — | EP | claimed |
| EP-0033241-A2 | Pharmaceutical compositions for rectal administration | Takeda Chemical Industries, Ltd. (JP) | 1981-08-05 | — | — | EP | claimed |
| EP-0004925-A1 | Synergistic mixtures of antibiotics and process for their production | CIBA-GEIGY AG (CH) | 1979-10-31 | — | — | EP | claimed |