Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotiam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.99 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.58 |
| ▸ | PGR | P06401 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.51 |
| ▸ | SLC22A8 | Q8TCC7 | 3/20 | 0.51 |
| ▸ | SLC22A11 | Q9NSA0 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotiam SCHEMBL6019446 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL11095123 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL16473046 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL149538 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL9754126 | 1.00 | TDP1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL65480 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL11065530 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL27767071 | 0.99 | TDP1 (0.99) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL193845 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 | |
| Cefotiam SCHEMBL10899868 | 0.99 | L3MBTL1 (1.00) | TDP1LMNAHSD17B10L3MBTL1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991017996-A1 | CEPHALOSPORIN ESTERS WHICH ARE USEFUL AS ANTIBIOTICS | THE UPJOHN COMPANY (US) | 1991-11-28 | — | — | WO | disclosed |
| US-4801703-A | PHOSPHORUS COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-01-31 | — | — | US | disclosed |
| US-4642365-A | REACTING A PYROCATECHOL DERIVATIVE AND DIHALOPHOSPHOROUS COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-02-10 | — | — | US | disclosed |