Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL3505984 | 0.92 | DNMT1 (0.37) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL7996887 | 0.92 | DNMT1 (0.37) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL9678206 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL23087090 | 0.88 | DNMT1 (0.38) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL62271 | 0.87 | DNMT1 (0.42) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL3903553 | 0.87 | DNMT1 (0.42) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL1445124 | 0.86 | TP53 (0.38) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL11314127 | 0.86 | DNMT1 (0.37) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL5800741 | 0.86 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Edetic Acid SCHEMBL4225221 | 0.83 | TDP1 (0.37) | DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190202919-A1 | PURIFICATION OF ANTI-C-MET ANTIBODIES | GENENTECH, INC. (US) | 2019-07-04 | — | — | US | disclosed |
| US-20150050275-A1 | PURIFICATION OF ANTI-C-MET ANTIBODIES | GENENTECH, INC. (US) | 2015-02-19 | — | — | US | disclosed |
| US-20130129718-A1 | PURIFICATION OF ANTI-C-MET ANTIBODIES | GENENTECH, INC. (US) | 2013-05-23 | — | — | US | disclosed |