⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290810 | 0.83 | TUBB1 (0.31) | — | |
| SCHEMBL2291930 | 0.81 | — | — | |
| SCHEMBL2290875 | 0.81 | — | — | |
| SCHEMBL28137883 | 0.73 | ALDH1A1 (0.35) | — | |
| SCHEMBL14480386 | 0.72 | — | — | |
| SCHEMBL2289049 | 0.69 | — | — | |
| SCHEMBL27887432 | 0.69 | — | — | |
| SCHEMBL2287605 | 0.67 | CA12 (0.35) | — | |
| SCHEMBL455674 | 0.67 | — | — | |
| SCHEMBL5917278 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106414429-B | Pyrazole compounds and their use as T-type calcium channel blockers | 爱杜西亚药品有限公司 | 2020-01-03 | — | — | CN | claimed |
| US-10065929-B2 | Pyrazole compounds and their use as T-type calcium channel blockers | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-09-04 | — | — | US | claimed |
| US-20180105496-A1 | PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-04-19 | — | — | US | claimed |
| US-9932314-B2 | Pyrazole compounds and their use as T-type calcium channel blockers | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-04-03 | — | — | US | claimed |
| EP-3152199-A1 | PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS | Actelion Pharmaceuticals Ltd. (CH) | 2017-04-12 | — | — | EP | claimed |
| US-20170096399-A1 | PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-04-06 | — | — | US | claimed |
| EP-1392687-B1 | 1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS | JANSSEN PHARMACEUTICALS INC (US) | 2017-02-01 | — | — | EP | claimed |
| US-9452997-B2 | Piperidine and piperazine derivatives as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2016-09-27 | — | — | US | claimed |
| WO-2015186056-A1 | PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-12-10 | — | — | WO | claimed |
| US-20140343075-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | US | claimed |
| US-6369069-B1 | CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-09 | — | — | US | claimed |
| CN-1035539-C | Hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient | NIPPON KAYAKU KK (JP) | 1997-08-06 | — | — | CN | claimed |
| EP-0496342-B1 | New hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient | NIPPON KAYAKU KK (JP) | 1996-11-27 | — | — | EP | claimed |
| US-5530021-A | AGRICULTURAL INSECTICIDES | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1996-06-25 | — | — | US | claimed |
| US-5378726-A | Insecticide, parasiticide | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1995-01-03 | — | — | US | claimed |
| US-5164400-A | Enzyme inhibitors, anticholesterol, antilipemic | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-17 | — | — | US | claimed |
| CN-1063488-A | It is the insect-killing composition of active ingredient that hydrazine derivative reaches with this derivative | NIPPON KAYAKU KK (JP) | 1992-08-12 | — | — | CN | claimed |
| EP-0496342-A1 | New hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-07-29 | — | — | EP | claimed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | claimed |
| EP-0414023-A2 | Pyrroloquinoline compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-27 | — | — | EP | claimed |