SCHEMBL28137883

SCHEMBL28137883

Cc1cc(-c2c[c]cc(-c3cc(C)c(F)c(C)c3)c2)cc(C)c1F

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17540392 0.82 ALDH1A1 (0.47) ALDH1A1TP53CYP3A4TSHRTDP1
SCHEMBL9646722 0.74 ALDH1A1 (0.33) ALDH1A1TP53CYP3A4TSHRTDP1
SCHEMBL149586 0.73
SCHEMBL28147076 0.73 CYP3A4 (0.43) ALDH1A1TP53CYP3A4TSHRTDP1
SCHEMBL2449542 0.72 RXRA (0.37) ALDH1A1TSHR
SCHEMBL19186972 0.68 ACHE (0.43) ALDH1A1TP53CYP3A4TSHRTDP1
SCHEMBL16122284 0.67 TSHR (0.35) ALDH1A1TP53CYP3A4TSHRTDP1
SCHEMBL2448202 0.65 ACHE (0.42) ALDH1A1TDP1CA1CA2
SCHEMBL7025202 0.64 RAPGEF4 (0.46) ALDH1A1TP53TSHRTDP1
SCHEMBL13550041 0.64 RAPGEF4 (0.37) CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106589348-A Polyarylether with main chain containing bisbenzofiurene and triaryl-s-triazine structure and preparation method of polyarylether 大连理工大学 2017-04-26 CN disclosed