Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 17/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 16/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 16/20 | 0.43 |
| ▸ | GABRP | O00591 | 14/20 | 0.43 |
| ▸ | GABRD | O14764 | 14/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 14/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 14/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 14/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 14/20 | 0.43 |
| ▸ | GABRE | P78334 | 14/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 14/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 14/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 14/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 14/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709935 | 0.94 | GABRB3 (0.48) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2840406 | 0.87 | GABRP (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL15887489 | 0.85 | GABRB3 (0.47) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL14958878 | 0.83 | GABRB3 (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL13134033 | 0.81 | GABRP (0.52) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2837055 | 0.81 | GABRB3 (0.50) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL13236567 | 0.80 | GABRB3 (0.49) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL4856859 | 0.78 | GABRP (0.59) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2833552 | 0.76 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL2838488 | 0.76 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035390-B1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL INC (US) | 2015-12-09 | — | — | EP | disclosed |
| US-8785372-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE | 2014-07-22 | — | — | US | disclosed |
| US-8445519-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE (FR) | 2013-05-21 | — | — | US | disclosed |