Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625005 | 0.84 | TDP1 (0.59) | TDP1POLBAPEX1SMN1; SMN2GAA | |
| SCHEMBL14415483 | 0.82 | TDP1 (0.62) | TDP1POLBAPEX1SMN1; SMN2GAA | |
| SCHEMBL1399311 | 0.81 | TDP1 (0.56) | TDP1POLBAPEX1SMN1; SMN2GAA | |
| SCHEMBL4462525 | 0.81 | TDP1 (0.56) | TDP1POLBAPEX1SMN1; SMN2GAA | |
| SCHEMBL14340565 | 0.81 | ALDH1A1 (0.48) | TDP1POLBAPEX1SMN1; SMN2HDAC4 | |
| SCHEMBL15920608 | 0.81 | HDAC4 (0.44) | TDP1POLBAPEX1HDAC4HDAC6 | |
| SCHEMBL10567198 | 0.81 | CA2 (0.56) | TDP1POLBAPEX1GAALMNA | |
| SCHEMBL171877 | 0.81 | CTBP2 (0.48) | TDP1POLBAPEX1CTBP2HDAC4 | |
| SCHEMBL1973647 | 0.81 | CA2 (0.56) | CTBP2HDAC4HDAC6LMNA | |
| SCHEMBL20888575 | 0.81 | CA12 (0.56) | TDP1POLBAPEX1SMN1; SMN2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445473-B2 | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-05-21 | — | — | US | disclosed |