Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.63 |
| ▸ | MMEL1 | Q495T6 | 7/20 | 0.63 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873241 | 0.79 | MMEL1 (0.74) | MMEMMEL1ITGB1ITGA4 | |
| SCHEMBL2873249 | 0.79 | MMEL1 (0.74) | MMEMMEL1ITGB1ITGA4 | |
| SCHEMBL2878314 | 0.79 | MMEL1 (0.74) | MMEMMEL1ITGB1ITGA4ROCK2 | |
| SCHEMBL2875506 | 0.78 | MME (1.00) | MMEMMEL1 | |
| SCHEMBL2875501 | 0.78 | MME (1.00) | MMEMMEL1 | |
| SCHEMBL2865977 | 0.78 | MME (0.61) | MMEMMEL1ITGB1ITGA4 | |
| SCHEMBL10197935 | 0.77 | MMEL1 (0.65) | MMEMMEL1 | |
| SCHEMBL14870674 | 0.73 | MME (0.66) | MMEMMEL1ITGB1ITGA4 | |
| SCHEMBL10197781 | 0.72 | MMEL1 (0.54) | MMEMMEL1 | |
| SCHEMBL14873511 | 0.72 | MME (0.63) | MMEMMEL1ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594556-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |