Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.63 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.63 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870674 | 0.81 | MME (0.66) | MMEMMEL1ITGA4ITGB1PPARG | |
| SCHEMBL2875501 | 0.78 | MME (1.00) | MMEMMEL1 | |
| SCHEMBL2875506 | 0.78 | MME (1.00) | MMEMMEL1 | |
| SCHEMBL15939858 | 0.76 | MMEL1 (0.74) | MMEMMEL1ITGA4ITGB1 | |
| SCHEMBL7446938 | 0.73 | MME (0.63) | MMEMMEL1ITGA4ITGB1PPARG | |
| SCHEMBL2878314 | 0.72 | MMEL1 (0.74) | MMEMMEL1ITGA4ITGB1ITGB7 | |
| SCHEMBL2873249 | 0.72 | MMEL1 (0.74) | MMEMMEL1ITGA4ITGB1 | |
| SCHEMBL14959402 | 0.72 | MME (0.63) | MMEMMEL1ITGA4ITGB1 | |
| SCHEMBL2873241 | 0.72 | MMEL1 (0.74) | MMEMMEL1ITGA4ITGB1 | |
| SCHEMBL14873420 | 0.71 | MMEL1 (0.60) | MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-B1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-20130096127-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096127-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | MME, AGTR1, REN | MME 1/4885MMEL1 299/4885ITGA4 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.