Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 8/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975716 | 1.00 | MMEL1 (0.43) | MMEL1CTSSCTSKATMMME | |
| SCHEMBL10197522 | 0.91 | MMEL1 (0.52) | MMEL1ATMMMECACNA1BKDM4E | |
| SCHEMBL8581787 | 0.90 | MMEL1 (0.44) | MMEL1CTSSCTSKATMMME | |
| SCHEMBL2878350 | 0.89 | MMEL1 (0.55) | MMEL1CTSSCTSKATMMME | |
| SCHEMBL10198332 | 0.88 | MMEL1 (0.58) | MMEL1CTSSCTSKATMMME | |
| SCHEMBL16133117 | 0.87 | MMEL1 (0.45) | MMEL1MME | |
| SCHEMBL8552371 | 0.86 | MME (0.50) | MMEL1MMEACE | |
| SCHEMBL12975711 | 0.84 | MME (0.52) | MMEL1CTSSCTSKATMMME | |
| SCHEMBL14952845 | 0.83 | MMEL1 (0.64) | MMEL1MME | |
| SCHEMBL12974944 | 0.83 | MMEL1 (0.56) | MMEL1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594556-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |