Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 2/20 | 0.50 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372913 | 0.89 | HSPB1 (0.58) | HSPB1PNLIPAPPARSLC6A4 | |
| SCHEMBL10664102 | 0.85 | TAAR5 (0.49) | HSPB1PNLIPAPP | |
| SCHEMBL15596855 | 0.85 | CYP1A2 (0.47) | HSPB1PNLIPAPPSLC6A4SCN9A | |
| SCHEMBL15596867 | 0.85 | MAP2K1 (0.48) | HSPB1SLC6A4MAP2K1LMNAL3MBTL1 | |
| SCHEMBL16023942 | 0.81 | CARM1 (0.44) | HSPB1APPSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL15596849 | 0.81 | AR (0.44) | HSPB1ARSLC6A4MAP2K1SCN9A | |
| SCHEMBL14965305 | 0.78 | CYP1A2 (0.47) | HSPB1SLC6A4SLC6A2SLC6A3SCN9A | |
| SCHEMBL16023941 | 0.78 | SLC6A4 (0.41) | HSPB1APPSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL13860118 | 0.77 | HSPB1 (0.42) | HSPB1APPARSLC6A4SLC6A2 | |
| SCHEMBL3024118 | 0.77 | HSPB1 (0.50) | HSPB1PNLIPARSLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |