Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28372328 | 0.98 | TDP1 (0.62) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL28947786 | 0.85 | CYP1A2 (0.64) | TDP1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11655261 | 0.84 | TDP1 (0.64) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL7183375 | 0.84 | TDP1 (0.56) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL7177957 | 0.84 | TDP1 (0.56) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL7177996 | 0.84 | TDP1 (0.56) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| 2,4-Dichlorophenoxyacetic Acid, Methyl Ester SCHEMBL5004223 | 0.84 | MAPT (0.70) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL9974137 | 0.83 | TDP1 (0.72) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL27410860 | 0.83 | TDP1 (0.62) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL4644003 | 0.82 | LMNA (0.70) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945798-B1 | METHOD FOR DETERMINING THE CLEAVABILITY OF SUBSTRATES | FORSCHUNGSZENTRUM BORSTEL (DE) | 2013-05-22 | — | — | EP | disclosed |