Sugi Predict

Sugi Predict / Compounds / SCHEMBL9974137

SCHEMBL9974137

SCHEMBL9974137

CC(=O)COc1ccc(Cl)cc1Cl

nearest known ligand 0.72

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 3/20 0.72
▸ TSHR P16473 2/20 0.69
▸ SMN1; SMN2 Q16637 3/20 0.63
▸ MEN1 O00255 1/20 0.62
▸ KMT2A Q03164 1/20 0.62
▸ L3MBTL1 Q9Y468 2/20 0.60
▸ ALDH1A1 P00352 1/20 0.60
▸ HTT P42858 1/20 0.59
▸ LMNA P02545 2/20 0.58
▸ POLB P06746 1/20 0.58
▸ MAPT P10636 3/20 0.57
▸ GAA P10253 1/20 0.57
▸ HPGD P15428 1/20 0.57
▸ ALOX12 P18054 1/20 0.57
▸ NPSR1 Q6W5P4 1/20 0.57
▸ NPC1 O15118 1/20 0.56
▸ RAB9A P51151 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5143188 0.89 TDP1 (0.58) TDP1TSHRSMN1; SMN2MEN1KMT2A
2,4-Dichlorophenoxyacetic Acid SCHEMBL23242752 0.84 TDP1 (0.93) TDP1TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL15255807 0.84 TDP1 (0.51) TDP1TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL8605798 0.84 CYP1A2 (0.64) TDP1TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL11639157 0.84 TDP1 (0.74) TDP1TSHRSMN1; SMN2MEN1KMT2A
2,4-Dichlorophenoxyacetic Acid SCHEMBL27783 0.84 TDP1 (1.00) TDP1TSHRSMN1; SMN2HTTMAPT
2,4-Dichlorophenoxyacetic Acid SCHEMBL31108925 0.84 TDP1 (1.00) TDP1TSHRSMN1; SMN2HTTMAPT
2,4-Dichlorophenoxyacetic Acid SCHEMBL226803 0.84 TDP1 (1.00) TDP1TSHRSMN1; SMN2HTTMAPT
2,4-Dichlorophenoxyacetic Acid SCHEMBL11716042 0.84 TDP1 (1.00) TDP1TSHRSMN1; SMN2HTTMAPT
SCHEMBL2538911 0.84 TDP1 (0.74) TDP1TSHRSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024031002-A1 (2,4-DICHLOROPHENOXY)ACETIC ACID ANALOGS CORTEVA AGRISCIENCE LLC (US) 2024-02-08 — — WO disclosed
US-20230210111-A1 HERBICIDAL MIXTURES AND COMPOSITIONS AND METHODS OF USE SBM Developpement SAS (FR) 2023-07-06 — — US disclosed
EP-3235799-B1 OXIME COMPOUND AND HERBICIDE NISSAN CHEMICAL CORP (JP) 2022-02-23 — — EP disclosed
WO-2021252644-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF Pardes Biosciences, Inc. (US) 2021-12-16 — — WO disclosed
CN-109776301-B Synthesis method of 2, 4-dichlorophenoxyacetic acid compound 黑龙江大学 2021-11-16 — — CN disclosed
US-11000033-B2 Ketone or oxime compound, and herbicide NISSAN CHEMICAL CORPORATION (JP) 2021-05-11 — — US disclosed
EP-3082429-B1 SYNERGISTIC HERBICIDAL WEED CONTROL DOW AGROSCIENCES LLC (US) 2020-10-28 — — EP disclosed
CN-109776301-A The synthetic method of one kind 2,4- dichlorphenoxyacetic acid compound 黑龙江大学 2019-05-21 — — CN disclosed
US-20190053488-A1 KETONE OR OXIME COMPOUND, AND HERBICIDE NISSAN CHEMICAL CORPORATION (JP) 2019-02-21 — — US disclosed
US-20170347647-A1 KETONE OR OXIME COMPOUND, AND HERBICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-12-07 — — US disclosed
US-8202861-B2 Drugs for various disorders VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-06-19 — — US disclosed
US-8153655-B2 Compositions useful as inhibitors of voltage-gated sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-04-10 — — US disclosed
US-8022063-B2 CRTH2 receptor ligands for medicinal uses 7TM PHARMA A/S (DK) 2011-09-20 — — US disclosed
EP-2336113-A1 CRTH2 Receptor Ligands for Medical Use 7TM Pharma A/S (DK) 2011-06-22 — — EP disclosed
EP-2308977-A2 Novel herbicide resistance gene Dow AgroSciences LLC (US) 2011-04-13 — — EP disclosed
EP-2298901-A2 Novel herbicide resistance genes Dow AgroSciences LLC (US) 2011-03-23 — — EP disclosed
CN-101857544-A Synthesis method of herbicide 2, 4-dichlorphenoxyacetic acid ACHIEVER BIOCHEM CO LTD 2010-10-13 — — CN disclosed
US-20100162620-A1 Optimization of Algal Product Production through Uncoupling Cell Proliferation and Algal Product Production McCarter & English, LLP 2010-07-01 — — US disclosed
US-20100087479-A1 Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-04-08 — — US disclosed
US-20090099189-A1 CRTH2 Receptor Ligands For Medicinal Uses 7TM PHARMA A/S (DK) 2009-04-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11000033-B2 Ketone or oxime compound, and herbicide OR10J3, CYP1B1, CBR3 TDP1 3660/4885TSHR 1268/4885SMN1; SMN2 2843/4885
US-20230210111-A1 HERBICIDAL MIXTURES AND COMPOSITIONS AND METHODS OF USE DDT, DCPS, MPHOSPH6 TDP1 1640/4885TSHR 2933/4885SMN1; SMN2 3562/4885
US-20100087479-A1 Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels SCNN1G, KCNN3, KCNN2 TDP1 2356/4885TSHR 4176/4885SMN1; SMN2 524/4885
US-20090099189-A1 CRTH2 Receptor Ligands For Medicinal Uses HRH1, HRH2, HRH3 TDP1 4874/4885TSHR 586/4885SMN1; SMN2 4722/4885
US-20190053488-A1 KETONE OR OXIME COMPOUND, AND HERBICIDE OR10J3, CYP1B1, CBR3 TDP1 3677/4885TSHR 1310/4885SMN1; SMN2 2838/4885
US-20170347647-A1 KETONE OR OXIME COMPOUND, AND HERBICIDE OR10J3, CYP1B1, CBR3 TDP1 3677/4885TSHR 1310/4885SMN1; SMN2 2838/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.