Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352030 | 0.80 | FGFR1 (0.35) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL29854726 | 0.80 | FGFR1 (0.35) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL17129283 | 0.79 | PRMT5 (0.32) | — | |
| SCHEMBL18559451 | 0.79 | FGFR1 (0.35) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL31240654 | 0.76 | FGFR1 (0.39) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL2038788 | 0.76 | FGFR1 (0.39) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL2797578 | 0.72 | ENPP3 (0.39) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL14377366 | 0.71 | MGAM (0.30) | — | |
| SCHEMBL18510392 | 0.66 | ENPP3 (0.42) | FGFR1FGFR4ENPP3ENPP1 | |
| SCHEMBL16888474 | 0.65 | ABL1 (0.49) | FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150315185-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2015-11-05 | — | — | US | disclosed |
| US-9090611-B2 | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as janus kinase inhibitors | INCYTE CORPORATION (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140228346-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2014-08-14 | — | — | US | disclosed |
| US-8741895-B2 | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2014-06-03 | — | — | US | disclosed |
| US-20130296299-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2013-11-07 | — | — | US | disclosed |
| US-8445488-B2 | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2013-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296299-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | FGFR1 990/4885FGFR4 831/4885ENPP3 749/4885 |
| US-20150315185-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | FGFR1 990/4885FGFR4 831/4885ENPP3 749/4885 |
| US-20140228346-A1 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | FGFR1 990/4885FGFR4 831/4885ENPP3 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.