Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21312957 | 0.85 | MKNK2 (0.31) | MKNK2 | |
| SCHEMBL19000557 | 0.81 | MKNK2 (0.33) | PRMT5WDR77MKNK2 | |
| SCHEMBL13243594 | 0.79 | DGAT1 (0.38) | PRMT5WDR77MKNK2 | |
| SCHEMBL14959883 | 0.79 | FGFR1 (0.33) | — | |
| SCHEMBL19011382 | 0.78 | MKNK2 (0.32) | MKNK2 | |
| SCHEMBL19790098 | 0.78 | MKNK2 (0.32) | MKNK2 | |
| SCHEMBL15281186 | 0.73 | MKNK2 (0.34) | PRMT5WDR77MKNK2 | |
| SCHEMBL26153000 | 0.72 | TLR7 (0.38) | PRMT5WDR77MKNK2 | |
| SCHEMBL15274062 | 0.72 | MKNK2 (0.34) | PRMT5WDR77MKNK2 | |
| SCHEMBL19711212 | 0.70 | ADORA2A (0.39) | PRMT5WDR77MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015144799-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRAZINE DERIVATIVES AND 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO[1,5-a][1,4]DIAZEPINE DERIVATIVES AS ROS1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-01 | — | — | WO | disclosed |