SCHEMBL14960255

SCHEMBL14960255

COC(=O)/C=C/C[C@@H](C)[C@H](C)c1cncc(OC[C@@H]2CCN2C(=O)OC(C)(C)C)c1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.34
CHRNA3 P32297 2/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA4 P43681 1/20 0.34
ALOX5AP P20292 2/20 0.34
FEN1 P39748 1/20 0.34
GPR119 Q8TDV5 2/20 0.33
ADORA2B P29275 4/20 0.33
IRAK4 Q9NWZ3 1/20 0.32
CHRNA2 Q15822 1/20 0.32
F2RL3 Q96RI0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14960250 0.88 CHRNB2 (0.37) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL14960252 0.84 CHRNB2 (0.39) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL7928916 0.83 DAPK3 (0.39) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL14960253 0.81 CHRNB2 (0.38) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL3357831 0.79 CHRNB2 (0.45) CHRNB2CHRNA3CHRNA4
SCHEMBL3357835 0.79 CHRNB2 (0.45) CHRNB2CHRNA3CHRNA4
SCHEMBL7465912 0.76 CHRNB2 (0.57) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL7475438 0.75 CHRNB2 (0.45) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL7475109 0.75 CHRNB2 (0.54) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP
SCHEMBL7475269 0.74 CHRNB2 (0.48) CHRNB2CHRNA3CHRNB4CHRNA4ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8445684-B2 Nicotinic acetylcholine receptor ligands and the uses thereof PsycoGenics Inc. (US) 2013-05-21 US disclosed