Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.35 |
| ▸ | HTR2B | P41595 | 8/20 | 0.35 |
| ▸ | MAOB | P27338 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 6/20 | 0.31 |
| ▸ | KDM1A | O60341 | 4/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564187 | 0.82 | RECQL (0.33) | HTR2CHTR2BMAOBHTR2ARECQL | |
| SCHEMBL4479260 | 0.76 | MAOB (0.34) | HTR2CMAOBRECQLSLC6A2SLC6A3 | |
| SCHEMBL19456953 | 0.73 | NR4A2 (0.35) | KDM1A | |
| SCHEMBL24316682 | 0.72 | RECQL (0.32) | HTR2CMAOBRECQLSLC6A2SLC6A3 | |
| SCHEMBL12719938 | 0.72 | RECQL (0.32) | HTR2CMAOBRECQLSLC6A2SLC6A3 | |
| SCHEMBL12087540 | 0.72 | HDAC4 (0.34) | HTR2CMAOBRECQLSLC6A2SLC6A3 | |
| SCHEMBL28675583 | 0.70 | RECQL (0.31) | MAOBRECQLMAOAKDM1A | |
| SCHEMBL4781477 | 0.69 | ALDH1A1 (0.40) | MAOBMAOAKDM1A | |
| SCHEMBL3430409 | 0.69 | PARP1 (0.35) | RECQLMAOAKDM1ACYP2C19CYP3A4 | |
| SCHEMBL6621183 | 0.69 | CA2 (0.35) | RECQLSLC6A3MAOAKDM1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445481-B2 | Scaffold-diversified pyrrolidinone derivatives and their use | THE UNIVERSITY OF CHICAGO (US) | 2013-05-21 | — | — | US | disclosed |