SCHEMBL14960688

SCHEMBL14960688

CN(NC(=O)CO)C(=O)c1cc(Br)cc(Br)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.37
▸ LMNA P02545 1/20 0.32
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ LRRK2 Q5S007 1/20 0.30
▸ RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12911779 0.92 DHODH (0.38) DHODHLMNAMEN1KMT2A
SCHEMBL14698541 0.92 DHODH (0.41) DHODHLMNAMEN1KMT2A
SCHEMBL13072418 0.91 DHODH (0.38) DHODHLMNAMEN1KMT2ARXFP1
SCHEMBL14961156 0.91 DHODH (0.37) DHODHLMNARXFP1
SCHEMBL31438694 0.90 DHODH (0.39) DHODHMEN1KMT2ALRRK2
SCHEMBL120823 0.90 DHODH (0.39) DHODHMEN1KMT2ALRRK2
SCHEMBL949995 0.90 DHODH (0.39) DHODHLMNAMEN1KMT2ALRRK2
SCHEMBL10028784 0.89 DHODH (0.41) DHODHLMNAMEN1KMT2ALRRK2
SCHEMBL14960687 0.89 DHODH (0.37) DHODHLMNAMEN1KMT2ALRRK2
SCHEMBL951388 0.88 DHODH (0.40) DHODHLMNAMEN1KMT2ALRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785646-B2 Process for producing amide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 — — US disclosed
US-8541613-B2 Process for producing amide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-09-24 — — US disclosed
US-8501951-B2 Process for producing amide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-06 — — US disclosed
US-20130131371-A1 PROCESS FOR PRODUCING AMIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed
US-20130131348-A1 PROCESS FOR PRODUCING AMIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed
US-20130131349-A1 PROCESS FOR PRODUCING AMIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131349-A1 PROCESS FOR PRODUCING AMIDE COMPOUND C9, F3, C5 DHODH 2693/4885LMNA 4146/4885MEN1 1865/4885
US-20130131371-A1 PROCESS FOR PRODUCING AMIDE COMPOUND C9, F3, C5 DHODH 2693/4885LMNA 4146/4885MEN1 1865/4885
US-20130131348-A1 PROCESS FOR PRODUCING AMIDE COMPOUND C9, F3, C5 DHODH 2693/4885LMNA 4146/4885MEN1 1865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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