SCHEMBL120823

SCHEMBL120823

COC(=O)NN(C)C(=O)c1cc(Br)cc(Br)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.39
MALT1 Q9UDY8 11/20 0.32
RBP4 P02753 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
LRRK2 Q5S007 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31438694 1.00 DHODH (0.39) DHODHMALT1RBP4MEN1KMT2A
SCHEMBL12911779 0.92 DHODH (0.38) DHODHMALT1MEN1KMT2A
SCHEMBL14698541 0.92 DHODH (0.41) DHODHMALT1MEN1KMT2A
SCHEMBL13072418 0.91 DHODH (0.38) DHODHMEN1KMT2A
SCHEMBL14960688 0.90 DHODH (0.37) DHODHMEN1KMT2ALRRK2
SCHEMBL949995 0.90 DHODH (0.39) DHODHMALT1MEN1KMT2ALRRK2
SCHEMBL30027678 0.90 DHODH (0.38) DHODHMALT1LRRK2
SCHEMBL29735306 0.90 DHODH (0.38) DHODHMALT1LRRK2
SCHEMBL797876 0.90 DHODH (0.38) DHODHMALT1LRRK2
SCHEMBL12559625 0.89 DHODH (0.40) DHODHMALT1RBP4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application BASF CORPORATION 2016-08-04 US claimed
US-9339030-B2 Foamable pesticide compositions and methods of application BASF CORPORATION (US) 2016-05-17 US claimed
US-20150105258-A1 Methods For Controlling Pests BASF CORPORATION (US) 2015-04-16 US claimed
US-8980294-B2 Methods for controlling pests BASF CORPORATION (US) 2015-03-17 US claimed
US-8940662-B2 Methods for controlling pests BASF CORPORATION (US) 2015-01-27 US claimed
US-20140013654-A1 Foamable Pesticide Compositions BASF CORPORATION 2014-01-16 US claimed
US-20140017216-A1 PESTICIDAL MIXTURES BAYER CROPSCIENCE LP (US) 2014-01-16 US claimed
EP-2654424-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING PYRAZOLE COMPOUNDS BASF SE (DE) 2013-10-30 EP claimed
US-20130125267-A1 Pesticidal Mixtures BASF SE (DE) 2013-05-16 US claimed
EP-2575471-A1 PESTICIDAL MIXTURES BASF SE (DE) 2013-04-10 EP claimed
JP-2011527307-A 2011-10-27 JP claimed
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I BASF SE (DE) 2011-05-19 US claimed
EP-2306837-A1 PESTCIDAL ACTIVE MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS I BASF SE (DE) 2011-04-13 EP claimed
WO-2011025789-A2 FOAMABLE PESTICIDE COMPOSITIONS AND METHODS OF APPLICATION BASF CORPORATION (US) 2011-03-03 WO claimed
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100322990-A1 METHODS FOR CONTROLLING PESTS BASF CORPORATION (US) 2010-12-23 US claimed
WO-2010129345-A2 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-11-11 WO claimed
WO-2010127019-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-11-04 WO claimed
WO-2010003923-A1 PESTCIDAL ACTIVE MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS I BASF SE (DE) 2010-01-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS DDT, PON1, ACHE DHODH 718/4885MALT1 4476/4885RBP4 447/4885
US-20130125267-A1 Pesticidal Mixtures DDT, CYP4B1, CYP4X1 DHODH 640/4885MALT1 4551/4885RBP4 3743/4885
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I CHRM3, CHRM5, CHRM1 DHODH 4306/4885MALT1 4326/4885RBP4 3465/4885
US-20100322990-A1 METHODS FOR CONTROLLING PESTS DDT, ACHE, PON1 DHODH 1877/4885MALT1 4338/4885RBP4 482/4885
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS DDT, ACHE, CHRM2 DHODH 2887/4885MALT1 2349/4885RBP4 944/4885
US-20140013654-A1 Foamable Pesticide Compositions DDT, PON1, ACHE DHODH 718/4885MALT1 4476/4885RBP4 447/4885
US-20150105258-A1 Methods For Controlling Pests DDT, ACHE, PON1 DHODH 1877/4885MALT1 4338/4885RBP4 482/4885
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application DDT, PLD1, ACHE DHODH 1116/4885MALT1 3749/4885RBP4 1905/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.